Scalable · Affordable · Joint Architecture
SaJa is a multi-modality, standards-based architecture that takes population-scale clinical and genetic screening from sample intake to a decision support report.
One pipeline that runs the same from a single clinic to a national programme. Horizontal compute, containerised stages, and versioned reference panels keep throughput linear as volume grows.
Cost is a design constraint, not an afterthought. Commodity sequencing, shared reference infrastructure, and open tooling drive the per-sample price toward the marginal cost of the assay.
A common architecture that labs, health systems, and researchers extend together. Shared schemas and open interfaces mean a variant curated once is trusted everywhere.
Six deterministic stages
Barcoded accessioning with chain-of-custody and consent metadata captured at source.
Automated, target-agnostic prep so the same workflow serves every panel.
Commodity short-read sequencing, pooled and multiplexed for cost efficiency.
Containerised alignment and joint calling against versioned reference panels.
Federated curation applies shared classification rules and known-variant evidence.
Clinical-grade report issued through an interoperable, auditable interface.
| Per-sample cost | Marginal | Approaches assay cost at scale |
|---|---|---|
| Throughput | 1 M+ | Samples per year, per node |
| Turnaround | 72 h | Intake to issued report |
| Coverage | 30× | Mean, screening-grade panels |
| Concordance | 99.9% | Against orthogonal reference |
| Interfaces | Open | Versioned interchange schemas |
Broad, low-cost coverage of actionable conditions at birth.
Reproductive risk assessment across recessive conditions.
Germline risk panels with federated variant evidence.
Drug-response markers routed into the same report.
Access the architecture
SaJa is open by design. Request the reference implementation, integration schemas, and deployment guidance for your lab or health system.
